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Compositions and methods for therapy and diagnosis of breast cancer

Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.

Breast cancer associated nucleic acid sequences and their associated proteins

This invention relates to the discovery of the association of certain nucleic acid sequences and proteins with breast cancer, the use of such sequences as a diagnostic indicator and treatments based on the association.

Compositions and methods for the therapy and diagnosis of breast cancer

Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.

Ligand antagonists for treatment of breast cancer

We have discovered that growth hormones form ternary complexes with their receptors in which site 1 on the hormone first binds to one molecule of receptor and then hormone site 2 then binds to another molecule of receptor, thereby producing a 1:2 complex. We believe this phenomenon is shared by other ligands having similar conformational structure. Assays based on this phenomenon are useful for identifying ligand agonists and antagonists. Sites 1 and 2 are structurally identified to facilitate generation of amino acid sequence variants of ternary complex-forming ligands. Novel variants of growth hormone, prolactin placental lactogen and other related ligands are provided. As a result of our studies with the ternary complex we have determined that selected antibodies to the receptor for these ligands are capable of acting as ligand agonists or antagonists. Novel growth hormones and novel uses for anti-growth hormone receptor antibodies are described. Methods for inhibiting the growth of breast cancer cells are also described.


51 6489101 Compositions and methods for therapy and diagnosis of breast cancer
52 6482600 Breast cancer associated nucleic acid sequences and their associated proteins
53 6432707 Compositions and methods for the therapy and diagnosis of breast cancer
54 6429186 Ligand antagonists for treatment of breast cancer
55 6423496 Compositions and methods for the treatment and diagnosis of breast cancer
56 6410507 Compounds for immunotherapy and diagnosis of breast cancer and methods for their use
57 6399328 Methods and compositions for diagnosis and treatment of breast cancer
58 6387697 Compositions for treatment and diagnosis of breast cancer and methods for their use
59 6379951 Compounds for immunotherapy of breast cancer and methods for their use
60 6368796 Methods of detection and treatment of breast cancer
61 6365348 Compounds for diagnosis of Breast cancer and methods for their use
62 6358683 Blood-based assays for breast cancer
63 6358682 Method and kit for the prognostication of breast cancer
64 6355427 Diagnostic assay for breast cancer susceptibility
65 6344550 Compositions and methods for the treatment and diagnosis of breast cancer
66 6342483 Method for detection and treatment of breast cancer
67 6338947 Methods for determining breast cancer and melanoma by assaying for a plurality of antigens associated therewith
68 6322989 Whole blood/mitogen assay for the early detection of a subject with ovarian or breast cancer and kit
69 6313277 Breast cancer resistance protein (BCRP) and the DNA which encodes it
70 6303634 Methods of preventing breast cancer
71 6300367 Composition for and method of preventing or treating breast cancer
72 6288039 Pharmaceutical compositions methods and kits for treatment and diagnosis of breast cancer
73 6282305 Method and system for the computerized assessment of breast cancer risk
74 6262054 Combination therapy method for treating breast cancer using edatrexate
75 6235486 Method for detection of breast cancer
76 6225054 Compositions and methods for the treatment and diagnosis of breast cancer
77 6218131 Materials and methods for detection of breast cancer
78 6211239 Method for treating or preventing breast cancer or leukemia using 6-[3-[1-adamantyl]-4-hydroxyphenyl]-2-naphthalene carboxylic acid (AHPN)
79 6208983 Method and apparatus for training and operating a neural network for detecting breast cancer
80 6207375 TGF-.beta. inducible early factor-1 (TIEF-1) and a method to detect breast cancer
81 6197532 Diagnosis and detection of breast cancer and other cancers
82 6179786 System for thermometry-based breast cancer risk-assessment
83 6179766 Methods of breast cancer treatment
84 6150421 Treatment of estrogen-receptor positive breast cancer and estrogen-receptor negative breast cancer with retinoid with CH.sub.2 OH at the side chain terminal position
85 6140050 Methods for determining breast cancer and melanoma by assaying for a plurality of antigens associated therewith
86 6124104 Chromosome 13-linked breast cancer susceptibility gene
87 6096718 Tissue specific adenovirus vectors for breast cancer treatment
88 6096301 Combined interferon/antiestrogen therapy for treatment of breast cancer
89 6086247 Differential temperature sensor device for use in the detection of breast cancer and breast disease
90 6066616 Somatostatin analogue composition and use in treating breast cancer
91 6056690 Method of diagnosing breast cancer
92 6040146 Detection of mammary tumor virus-like sequences in human breast cancer
93 6037129 Multi-marker RT-PCR panel for detecting metastatic breast cancer
94 6033857 Chromosome 13-linked breast cancer susceptibility gene
95 6027396 Brassieres for reducing breast cancer
96 6004756 Method for detecting the presence of breast cancer by detecting an increase in mammaglobin mRNA expression
97 5981218 Isolated nucleic acid molecules useful as leukemia markers and in breast cancer prognosis and encoded polypeptides
98 5981201 Methods of detection and treatment of breast cancer
99 5968754 Mammaglobin, a mammary-specific breast cancer protein
100 5914238 Materials and methods for detection of breast cancer
Glypican-1 in human breast cancer
Compositions and methods for therapy and diagnosis of breast cancer
Mammaglobin, a mammary-specific breast cancer protein
Method of diagnosing breast cancer and compositions therefor
Use of anastrozole for the treatment of post-menopausal women having early breast cancer
Compositions and methods for the therapy and diagnosis of breast cancer
Treatment of breast cancer
Apparatus and method for breast cancer imaging


51 6489101 Compositions and methods for therapy and diagnosis of breast cancer
52 6482600 Breast cancer associated nucleic acid sequences and their associated proteins
53 6432707 Compositions and methods for the therapy and diagnosis of breast cancer
54 6429186 Ligand antagonists for treatment of breast cancer
55 6423496 Compositions and methods for the treatment and diagnosis of breast cancer
56 6410507 Compounds for immunotherapy and diagnosis of breast cancer and methods for their use
57 6399328 Methods and compositions for diagnosis and treatment of breast cancer
58 6387697 Compositions for treatment and diagnosis of breast cancer and methods for their use
59 6379951 Compounds for immunotherapy of breast cancer and methods for their use
60 6368796 Methods of detection and treatment of breast cancer
61 6365348 Compounds for diagnosis of Breast cancer and methods for their use
62 6358683 Blood-based assays for breast cancer
63 6358682 Method and kit for the prognostication of breast cancer
64 6355427 Diagnostic assay for breast cancer susceptibility
65 6344550 Compositions and methods for the treatment and diagnosis of breast cancer
66 6342483 Method for detection and treatment of breast cancer
67 6338947 Methods for determining breast cancer and melanoma by assaying for a plurality of antigens associated therewith
68 6322989 Whole blood/mitogen assay for the early detection of a subject with ovarian or breast cancer and kit
69 6313277 Breast cancer resistance protein (BCRP) and the DNA which encodes it
70 6303634 Methods of preventing breast cancer
71 6300367 Composition for and method of preventing or treating breast cancer
72 6288039 Pharmaceutical compositions methods and kits for treatment and diagnosis of breast cancer
73 6282305 Method and system for the computerized assessment of breast cancer risk
74 6262054 Combination therapy method for treating breast cancer using edatrexate
75 6235486 Method for detection of breast cancer
76 6225054 Compositions and methods for the treatment and diagnosis of breast cancer
77 6218131 Materials and methods for detection of breast cancer
78 6211239 Method for treating or preventing breast cancer or leukemia using 6-[3-[1-adamantyl]-4-hydroxyphenyl]-2-naphthalene carboxylic acid (AHPN)
79 6208983 Method and apparatus for training and operating a neural network for detecting breast cancer
80 6207375 TGF-.beta. inducible early factor-1 (TIEF-1) and a method to detect breast cancer
81 6197532 Diagnosis and detection of breast cancer and other cancers
82 6179786 System for thermometry-based breast cancer risk-assessment
83 6179766 Methods of breast cancer treatment
84 6150421 Treatment of estrogen-receptor positive breast cancer and estrogen-receptor negative breast cancer with retinoid with CH.sub.2 OH at the side chain terminal position
85 6140050 Methods for determining breast cancer and melanoma by assaying for a plurality of antigens associated therewith
86 6124104 Chromosome 13-linked breast cancer susceptibility gene
87 6096718 Tissue specific adenovirus vectors for breast cancer treatment
88 6096301 Combined interferon/antiestrogen therapy for treatment of breast cancer
89 6086247 Differential temperature sensor device for use in the detection of breast cancer and breast disease
90 6066616 Somatostatin analogue composition and use in treating breast cancer
91 6056690 Method of diagnosing breast cancer
92 6040146 Detection of mammary tumor virus-like sequences in human breast cancer
93 6037129 Multi-marker RT-PCR panel for detecting metastatic breast cancer
94 6033857 Chromosome 13-linked breast cancer susceptibility gene
95 6027396 Brassieres for reducing breast cancer
96 6004756 Method for detecting the presence of breast cancer by detecting an increase in mammaglobin mRNA expression
97 5981218 Isolated nucleic acid molecules useful as leukemia markers and in breast cancer prognosis and encoded polypeptides
98 5981201 Methods of detection and treatment of breast cancer
99 5968754 Mammaglobin, a mammary-specific breast cancer protein
100 5914238 Materials and methods for detection of breast cancer

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