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Mammaglobin, a mammary-specific breast cancer protein

A purified and isolated DNA sequence and the encoded mammary-specific protein, mammaglobin, are disclosed. Also disclosed are methods for the detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA encoding mammaglobin.

Chromosome 13-linked breast cancer susceptibility gene

The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast cancer predisposing gene (BRCA2), some mutant alleles of which cause susceptibility to cancer, in particular breast cancer. More specifically, the invention relates to germline mutations in the BRCA2 gene and their use in the diagnosis of predisposition to breast cancer. The present invention further relates to somatic mutations in the BRCA2 gene in human breast cancer and their use in the diagnosis and prognosis of human breast cancer. Additionally, the invention relates to somatic mutations in the BRCA2 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the BRCA2 gene, including gene therapy, protein replacement therapy and protein mimetics. The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the BRCA2 gene for mutations, which are useful for diagnosing the predisposition to breast cancer.

Targets for breast cancer diagnosis and treatment

cDNA sequences derived from four novel genes associated with breast cancer are provided. In over about 60% of the cancer cell lines tested, RNA hybridizing with the cDNAs were substantially more abundant than in normal cells. Most of the cell lines also showed a duplication of the corresponding gene, which probably contributed to the increased level of RNA in the cell. However, for each of the four genes, there were some cell lines which had RNA overabundance without gene duplication. This suggests that the gene product is sufficiently important to the cancer process that cells will use several alternative mechanisms to achieve increased expression. The polynucleotides, polypeptides, and antibodies provided by this invention are expected to be particularly useful in diagnosis and treatment of breast cancer. Also provided is a general method for obtaining cDNA with similar properties that may be associated with breast cancer and other malignancies.

Somatostatin analogue composition and use in treating breast cancer

The invention provides a pharmaceutical composition containing a somatostatin analogue, and its use in the treatment of breast cancer. The pharmaceutical composition preferably contains lactic acid in addition to the somatostatin analogue and is better tolerated when administered by injection.

Glypican-1 in human breast cancer
Compositions and methods for therapy and diagnosis of breast cancer
Mammaglobin, a mammary-specific breast cancer protein
Method of diagnosing breast cancer and compositions therefor
Use of anastrozole for the treatment of post-menopausal women having early breast cancer
Compositions and methods for the therapy and diagnosis of breast cancer
Treatment of breast cancer
Apparatus and method for breast cancer imaging


101 5855889 Mammaglobin, a mammary-specific breast cancer protein
102 5837492 Chromosome 13-linked breast cancer susceptibility gene
103 5759776 Targets for breast cancer diagnosis and treatment
104 5753618 Somatostatin analogue composition and use in treating breast cancer
105 5741649 Method and kit for detecting breast cancer cells
106 5721345 Prevention of mammary carcinogenesis and breast cancer treatment
107 5686247 Detection of mammary tumor virus env gene-like sequences in human breast cancer
108 5668267 Polynucleotides encoding mammaglobin, a mammary-specific breast cancer protein
109 5648224 Method of determining the risk of breast cancer development
110 5593847 Monitoring of NC 50/90 in blood samples of breast cancer patients
111 5496846 Taxol treatment of breast cancer
112 5384260 Detection of onset of antiestrogen resistance in breast cancer
113 5236844 Analytical markers for malignant breast cancer
114 5169774 Monoclonal anti-human breast cancer antibodies
115 5130256 Diagnostic assay for breast cancer in human female patients
116 5119827 Mechanisms of antiestrogen resistance in breast cancer
117 5024833 Combined interferon/antiestrogen therapy for treatment of breast cancer
118 5023234 Combination male breast cancer therapy
119 4945239 Early detection of breast cancer using transillumination
120 4938948 Method for imaging breast tumors using labeled monoclonal anti-human breast cancer antibodies
121 4888163 Diagnostic agent for breast cancer or tumor
122 4882270 Monoclonal antibodies to placental isoferritin for use in detecting oncofetal ferritin associated with breast cancer and Hodgkins disease
123 4853221 Method for treating non-small cell lung cancer, head and neck cancers and breast cancer
124 4803169 Assay for human breast cancer
125 4775661 Combination therapy for treatment of female breast cancer
126 4775660 Treatment of breast cancer by combination therapy
127 4753894 Monoclonal anti-human breast cancer antibodies
128 4737109 Breast cancer detection training device
129 4707438 Immunoassay for breast cancer employing monoclonal antibodies
130 4666885 Combination therapy for treatment of female breast cancer
131 4657851 Breast cancer diagnostic blood test
132 4651749 Cancer detection patch for early detection of breast cancer
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134 4612282 Monoclonal antibodies reactive with human breast cancer
135 RE32000 Device for use in early detection of breast cancer
136 4522918 Process for producing monoclonal antibodies reactive with human breast cancer
137 4409200 Reverse transcriptase from human milk, method for its purification, and its use in the detection of breast cancer
138 4383985 Breast cancer antigens
139 4190058 Device for use in early detection of breast cancer
140 4134218 Breast cancer detection training system
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142 3999944 Detection of breast cancer

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