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Method of diagnosing breast cancer and compositions therefor

A method of diagnosing breast cancer in an individual aged younger than 41 or older than 54 is provided. The method comprises obtaining a nucleic acid from the individual and determining a nucleotide at a polymorphic site of the nucleic acid. Polynucleotides specific to breast cancer, a microarray comprising the polynucleotides, and diagnostic kits are also provided.

Beta-parvin expression for use in diagnostic methods for assessment of breast cancer

The invention is directed to polynucleotides encoding .beta.-parvin, a newly identified tumor suppressor gene the alteration of which is involved in the occurrence of breast cancer in a patient, as well as to corresponding expressed polypeptides. The invention also concerns diagnostic methods using the .beta.-parvin polynucleotides and/or peptides and embodiments thereof as diagnostic or therapeutic tools for breast cancer or in assays to identify pharmacological agents for the treatment of breast cancer.

Methods for identifying risk of breast cancer and treatments thereof

Provided herein are methods for identifying risk of breast cancer in a subject and/or a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating breast cancer, and therapeutic methods for treating breast cancer in a subject. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.

Polynucleotide associated with breast cancer comprising single nucleotide polymorphism, microarray and diagnostic kit comprising the same and method for diagnosing breast cancer using the same

Provided is a polynucleotide for diagnosis or treatment of breast cancer, including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID No: 1 to SEQ ID No: 5 and comprising a nucleotide at 101.sup.st position of the nucleotide sequence, or a complementary polynucleotide thereof.

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