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Treatment of breast cancer

A method of treating a patient with breast cancer includes administering to the patient a breast cancer cell proliferation-inhibiting amount of a methylol-containing compound such as taurolidine, taurultam or a mixture thereof.

Specific microarrays for breast cancer screening

Microarrays specific for breast cancer are provided. Also provided are methods for detecting breast cancer in patients or screening therapeutics for the treatment or prevention of breast cancer by analyzing expression levels of specific genes in BECs or quantifying specific protein levels in breast ductal fluid.

Basal cell markers in breast cancer and uses thereof

The invention provides a variety of reagents for use in the diagnosis and management of breast cancer. The invention utilizes cDNA microarray technology to identify genes whose expression profile across a large group of tumor samples correlates with that of cytokeratin 5 and cytokeratin 17, markers for basal cells of the normal mammary lactation gland. The invention demonstrates that tumors that express cytokeratin 5/6 and/or 17 have a poor prognosis relative to tumors overall. The invention provides basal marker genes and their expression products and uses of these genes for diagnosis of breast cancer and for identification of therapies for breast cancer. In particular, the invention provides basal marker genes including cadherin3, matrix metalloproteinase 14, and cadherin EGF LAG seven-pass G-type receptor 2. The invention provides antibodies to the polypeptides expressed by these genes and methods of use thereof.

Methods and compositions for detection of breast cancer

Systematic comparisons of breast ductal fluid samples obtained by nipple aspiration from women with unilateral breast cancer revealed significant differences in ductal fluid protein expression between the breast with cancer and the breast without cancer in each patient. This study demonstrates that breast ductal fluid contains over 1000 separate protein species and suggests that ductal fluids from breast cancer patients may be useful for high-throughput biomarker discovery.

Glypican-1 in human breast cancer
Compositions and methods for therapy and diagnosis of breast cancer
Mammaglobin, a mammary-specific breast cancer protein
Method of diagnosing breast cancer and compositions therefor
Use of anastrozole for the treatment of post-menopausal women having early breast cancer
Compositions and methods for the therapy and diagnosis of breast cancer
Treatment of breast cancer
Apparatus and method for breast cancer imaging


301 20030092707 Treatment of breast cancer
302 20030087265 Specific microarrays for breast cancer screening
303 20030086934 Basal cell markers in breast cancer and uses thereof
304 20030077832 Methods and compositions for detection of breast cancer
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306 20030064419 Proteins, genes and their use for diagnosis and treatment of breast cancer
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318 20030013766 Methods and pharmaceutical compositions for treatment of anti-estrogen resistant breast cancer using RXR Modulators
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340 20020085998 Compositions and methods for the therapy and diagnosis of breast cancer
341 20020082216 Compositions and methods for the therapy, diagnosis and monitoring of breast cancer
342 20020081609 Compositions and methods for the therapy and diagnosis of breast cancer
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346 20020019418 Methods of preventing breast cancer
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349 20020004239 Genes differentially expressed in breast cancer
350 20010047033 Composition for and method of preventing or treating breast cancer

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