A detector for use in a dedicated PET scanner for cancer applications,
particularly breast cancer applications, using a LSO scintillator,
a lightguide coupling arrangement, and an efficient way to construct
the scintillator array, which provides a flexible imaging system
for breast cancer applications with high sensitivity and high spatial
resolution in a compact, cost effective, design.
Compositions and methods for the therapy and diagnosis of cancer,
particularly breast cancer, are disclosed. Illustrative compositions
comprise one or more breast tumor polypeptides, immunogenic portions
thereof, polynucleotides that encode such polypeptides, antigen
presenting cell that expresses such polypeptides, and T cells that
are specific for cells expressing such polypeptides. The disclosed
compositions are useful, for example, in the diagnosis, prevention
and/or treatment of diseases, particularly breast cancer.
Compounds of this formula 1 are useful for preventing breast cancer.
The present invention relates generally to the field of human genetics.
Specifically, the present invention relates to the discovery that
some alleles of the A-T gene cause susceptibility to cancer, in
particular breast cancer. More specifically, the present invention
relates to germline mutations in the A-T gene and their use in the
diagnosis of predisposition to breast cancer. The invention further
relates to somatic mutations in the A-T gene in human breast cancer
and their use in the diagnosis and prognosis of human breast cancer.