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Methods for detection and diagnosing of breast cancer

Described herein are methods that can be used for diagnosis and prognosis of breast cancer. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate breast cancer. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in breast cancer are described.

Method and antibody for imaging breast cancer

The present invention provides a new method of detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating breast cancer.

Method of diagnosing, monitoring and staging breast cancer

The present invention provides a new method for detecting, diagnosing, monitoring, staging, and prognosticating breast cancer.

Treatment of breast cancer

Compounds of the class of 4-oxo-butenoic acid derivatives are disclosed along with the surprising use property of these compounds as a anti-tumor agents in humans against breast carcinoma, which include: 2-(N'-Fluoren-9-ylidene-hydrazino)5,5-dimethyl-4-oxo-hex-2-enoic acid methyl ester (OF-06), 1-(2,4-Dimethyl-phenyl)-2,4-dihydroxy-3-(4-methyl-benzoyl)-5-oxo-2,5-dihyd ro-1H-pyrrole-2-carboxylic acid methyl ester (1F-07), 4-(4-Methoxy-phenyl)-2,4-dioxo-3-(phenyl-hydrazono)-butyric acid (3F-10), 4-(4-Chloro-phenyl)-2,4-dioxo-3-(phenyl-hydrazono)-butyric acid ethyl ester (3F-11), 2-Hydroxy-4-oxo-4-(2,3,5,6-tetrafluoro-4-methoxy-phenyl)-but-2-enoic acid (3F-15), and 4,4-Dihydroxy-5-(4-methyl-benzoyl)-2-phenyl-2,4-dihydro-pyrazol-3-one (3F-16) as well as some novel derivatives of these compounds claimed (see Table 2). The invention also encompasses a class of the compounds with the novel property of anti-tumor activity against human breast cancer, which includes the following compounds 4-(4-Ethoxy-phenyl)-2-(N'-fluoren-9-ylidene-hydrazino)-2-hydroxy-4-oxo-but yric acid methyl ester (OF-13); 2-{N'-[1-(4-Chloro-phenyl)-ethylidene]-hydrazino}-4-oxo-4-phenyl-but-2-eno ic acid methyl ester (OF-20); 2-(N'-Fluoren-9-ylidene-hydrazino)-4-oxo-4-phenyl-but-2-enoic acid methyl ester (1F-04); and 4-Chloro-4-(4-ethoxy-phenyl)-2-(fluoren-9-ylidene-hydrazono)-but-3-enoic acid methyl ester (3F-19).

Glypican-1 in human breast cancer
Compositions and methods for therapy and diagnosis of breast cancer
Mammaglobin, a mammary-specific breast cancer protein
Method of diagnosing breast cancer and compositions therefor
Use of anastrozole for the treatment of post-menopausal women having early breast cancer
Compositions and methods for the therapy and diagnosis of breast cancer
Treatment of breast cancer
Apparatus and method for breast cancer imaging


1 7108986 Glypican-1 in human breast cancer
2 7105542 2-Heterosubstituted 3-aryl-4H-1-benzopyran-4-ones as novel therapeutics in breast cancer
3 7094775 Method of treating breast cancer using a combination of vitamin D analogues and other agents
4 7081517 Genes differentially expressed in breast cancer
5 7053193 Breast cancer transcription factor gene and uses
6 7008778 Breast cancer specific gene 1
7 6978788 Minimally invasive treatment for breast cancer
8 6969518 Compositions and methods for the therapy and diagnosis of breast cancer
9 6962928 Tetrahydroquinoline derivatives for the inhibition of osteoporosis, estrogen dependent breast cancer, endometriosis and uterine fibrosis
10 6958361 Compositions and methods for the therapy and diagnosis of breast cancer
11 6936424 Materials and methods for detection and treatment of breast cancer
12 6905833 Method of diagnosing breast cancer using nipple fluid
13 6901278 Methods for reducing the risk of breast cancer in and improving the health of women
14 6894026 Long-acting oxytocin analogues for the treatment and prevention of breast cancer and psychiatric disorders
15 6861506 Compositions and methods for the treatment and diagnosis of breast cancer
16 6855554 Methods and compositions for detection of breast cancer
17 6844325 Compositions for the treatment and diagnosis of breast cancer and methods for their use
18 6828431 Compositions and methods for the therapy and diagnosis of breast cancer
19 6821732 Methods and compositions in breast cancer diagnosis and therapeutics
20 6821725 Methods for the diagnosis and treatment of breast cancer
21 6780586 Methods of diagnosing breast cancer
22 6768925 Method for improved safety in externally focused microwave thermotherapy for treating breast cancer
23 6762020 Methods of diagnosing breast cancer
24 6756477 Compositions and methods for the therapy and diagnosis of breast cancer
25 6753418 Suppressors of human breast cancer cell growth
26 6750013 Methods for detection and diagnosing of breast cancer
27 6737040 Method and antibody for imaging breast cancer
28 6730477 Method of diagnosing, monitoring and staging breast cancer
29 6713503 Treatment of breast cancer
30 6703426 Treatment of breast cancer
31 6680197 Compositions and methods for the therapy and diagnosis of breast cancer
32 6677428 Mammaglobin, a secreted mammary-specific breast cancer protein
33 6656480 Compositions and methods for the treatment and diagnosis of breast cancer
34 6649342 Methods of diagnosing breast cancer, compositions, and methods of screening for breast cancer modulators
35 6638975 Treatment of breast cancer
36 6638733 G-protein coupled receptors amplified in breast cancer
37 6638727 Methods for identifying treating or monitoring asymptomatic patients for risk reduction or therapeutic treatment of breast cancer
38 6617104 Predisposition to breast cancer by mutations at the ataxia-telangiectasia genetic locus
39 6602907 Treatment of breast cancer
40 6590076 Compositions for the treatment and diagnosis of breast cancer and methods for their use
41 6586572 Compositions and methods for the therapy and diagnosis of breast cancer
42 6586570 Compositions and methods for the treatment and diagnosis of breast cancer
43 6579973 Compositions for the treatment and diagnosis of breast cancer and methods for their use
44 6573368 Compositions for the treatment and diagnosis of breast cancer and methods for their use
45 6566072 Mammaglobin, a secreted mammary-specific breast cancer protein
46 6562380 Methods for treating or reducing prediposition to breast cancer, pre-menstrual syndrome or symptoms associated with menopause by administration of phyto-estrogen
47 6552348 Apparatus and method for breast cancer imaging
48 6544742 Detection of genes regulated by EGF in breast cancer
49 6528054 Compositions and methods for the therapy and diagnosis of breast cancer
50 6518237 Compositions for treatment and diagnosis of breast cancer and methods for their use

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