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Hair Loss Patent

Dermatological/cosmetic compositions comprising antifungal and antibacterial compounds and reduction of hair loss therewith

Hair loss abstract


Dermatological/cosmetic compositions for reducing or decelerating human hair loss comprise an effective hair loss-reducing amount of combinatory immixture of (a) at least one antifungal agent and (b) at least one halogenated antibacterial agent other than a macrolide or pyranoside, characteristically formulated in a topically physiologically acceptable medium therefor.

Hair loss claims


What is claimed is:

1. A method for reducing or decelerating hair loss from a human in need of such treatment, comprising applying to the site of such hair loss, an effective amount of a dermatological/cosmetic composition of matter, comprising an effective hair-loss reducing amount of a combinatory mixture of (a) 1-hydroxy-4-methyl-6(2,4,4-trimethyl-pentyl)-2-(1H)-pyridone and (b)-5-chloro-2-(2,4-dichlorophenoxy)phenol,

wherein (a) comprises from 0.01% to 5% by weight of said composition and (b) comprises from 0.01% to 10% by weight of said composition.

2. The method of claim 1, wherein (a) comprises from 0.1% to 2% by weight of said composition.

3. The method of claim 1, wherein (b) comprises from 0.1% to 2% by weight of said composition.

4. The method of claim 1, wherein the weight ratio of (a) to (b) ranges from 0.2 to 10.

5. The method of claim 1, wherein the composition is formulated into a topically physiologically acceptable medium.

6. The method of claim 5, wherein the composition is in the form of a lotion, shampoo, foam, cream, gel, ointment, salve, milk, stick, spray, balm, emulsion, powder, or solid or liquid soap.

7. The method of claim 6, wherein the composition further comprises at least one topically pharmaceutically acceptable additive or adjuvant.

8. The method of claim 7, wherein said at least one additive or adjuvant is a thickening agent, preservative, stabilizer, pH regulator, osmotic pressure modifier, emulsifying agent, sunscreen agent, antioxidant, fragrance, colorant, polymer, surface-active agent, or mixture thereof.

Hair loss description

BACKGROUND OF THE INVENTION

1. Technical Field of the Invention

The present invention relates to novel dermatological/cosmetic compositions comprising at least one antifungal agent and at least one halogenated antibacterial agent, other than those of the genera macrolide and pyranoside, and to topical applications thereof for the reduction of hair loss.

2. Description of the Prior Art

It has long been known to this art that natural hair loss in humans reflects the overall equilibrium of hair follicles between the alternating growth phases (anagenic phases) and the hair loss phases (telogenic phases). The average ratio of the number of follicles in the anagenic phase to that in the telogenic phase is on the order of 9 (90/10). The percentage of follicles in the rest or quiescent phase (catagenic phase) appears to be very low.

Natural hair loss may be estimated, on average, to be a few hundred hairs per day for a normal physiological state. For a pathological physiological state, this number may attain a value of several hundred per day, leading to alopecia.

Moreover, a microbiological flora exists at the surface of the scalp, this flora consisting naturally of bacteria and yeasts. When an imbalance occurs in the natural composition of this flora, hair loss may be increased.

It too is known, moreover, that certain factors such as hormonal imbalance, physiological stress or food deficiencies may accelerate the phenomenon.

In order to reduce hair loss, FR-2,618,068 describes treatment of the scalp with a composition containing an antifungal agent which is optionally combined with an anti-inflammatory agent and/or with an antibiotic agent selected from among the macrolides or the pyranosides. However, such compositions are not entirely satisfactory since, although the reduction of hair loss is more pronounced than with treatment using an antifungal agent alone, topical application of anti-inflammatory agents have a tendency to bring about variations in the natural composition of the microbiological flora, thereby increasing the risks of infection.

Antibiotic agents are not entirely satisfactory either, since they are often unstable in cosmetic or dermatological compositions. In addition, they promote bacterial resistance phenomena, thus resulting in lesser effectiveness of the compositions intended to reduce or decelerate hair loss.

The topical application of antibacterial agents does not promote these resistance phenomena, but it appears that most of the conventional antibacterial agents inhibit the action of antifungal agents, thereby also reducing the effectiveness of compositions containing this type of combination.

SUMMARY OF THE INVENTION

It has now unexpectedly been determined that compositions intended to reduce or decelerate hair loss and containing an antifungal agent are more effective when this agent is combined with a halogenated antibacterial agent not of the macrolide and pyranoside families; surprisingly, these halogenated antibacterial agents do not inhibit the action of antifungal agents as is the case with the nonhalogenated antibacterial agents.

In addition, such halogenated antibacterial agents are very stable when they are formulated into the compositions of the invention and they promote no bacterial resistance.

Briefly, the present invention thus features novel dermatological/cosmetic compositions comprising at least one antifungal agent and at least one halogenated antibacterial agent, other than those of the genera macrolide and pyranoside, and to topical applications thereof for the reduction of hair loss.

DETAILED DESCRIPTION OF BEST MODE AND PREFERRED EMBODIMENTS OF THE INVENTION

More particularly according to the present invention, it is observed that after a few weeks of treatment, the appearance of the hair is improved, and the hair is, in particular, shinier, lighter and less greasy.

According to the invention, by the term "antifungal agent" is intended any substance capable of inhibiting or preventing the growth of yeasts, in particular those found at the surface of the epidermis which is rich in sebaceous glands and especially at the surface of the scalp such as, for example, Pityrosporum ovale and varieties thereof (Pityrosporum orbiculare and Malassezia furfur).

Among the antifungal agents suitable for formulation according to the invention, particularly representative are terbinafine, zinc pyrithione, selenium sulfide, tars and derivatives thereof, undecylenic acid and salts thereof and hydroxypyridone derivatives such as CICLOPIROX, i.e., 6-cyclohexyl-1-hydroxy-4-methyl-2-(1H)-pyridone, or OCTOPIROX, i.e., 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)-pyridone.

These antifungal agents are preferably present in the compositions in accordance with this invention at a concentration ranging from 0.01% to 5% by weight approximately relative to the total weight of the composition. Even more preferably, the concentration of antifungal agents may range from 0.1% to 2% by weight relative to the total weight of the composition.

Also according to the invention, by the term "halogenated antibacterial agent" is intended any substance containing at least one halogen atom and capable of inhibiting or preventing the growth of the bacterial flora present at the surface of epidermis which is rich in sebaceous glands.

The halogenated antibacterial agents according to the present invention are preferably benzene derivatives.

Among the halogenated antibacterial agents suitable for formulation according to the invention, particularly exemplary are chlorinated antibacterial agents such as triclosan, i.e., 5-chloro-2-(2,4-dichlorophenoxy)phenol, marketed under the trademark IRGASAN by Ciba-Geigy, chlorhexidine and derivatives thereof, chloramphenicol and 1-(4-chlorophenoxy)-1-(1H-imidazolyl)-3,3-dimethyl-2-butanone, marketed under the trademark CLIMBAZOLE by Bayer. These halogenated antibacterial agents are preferably present in the compositions in accordance with the invention at a concentration which may range from 0.01% to 10% by weight approximately relative to the total weight of the composition. Even more preferably, the concentration of antibacterial agents may range from 0.1% to 2% by weight relative to the total weight of the composition.

The weight ratio of the antifungal agents to the halogenated antibacterial agents may vary over wide limits. In particular, this weight ratio preferably ranges from 0.2 to 10.

The compositions in accordance with this invention may be in various forms typically employed in cosmetics or in dermatology for the treatment of the scalp.

They may, more particularly, be formulated with a topically physiologically (dermatologically/cosmetically) cosmetically) acceptable vehicle, carrier or diluent in the form of lotions, shampoos, foams, creams, gels, sticks, sprays, balms, ointments, milks, salves, emulsions, powders, or solid or liquid soaps.

The physiologically acceptable medium generally comprises water or of a mixture of water and at least one organic solvent which is physiologically acceptable for the purpose of a topical application. Among these solvents, exemplary are acetone, C.sub.1 -C.sub.4 lower alcohols such as ethanol and isopropyl alcohol, alkylene glycols such as ethylene glycol and propylene glycol, ethylene glycol monomethyl, monoethyl or monobutyl ethers, the monoethyl ethers of propylene glycol and of dipropylene glycol, the C.sub.1 -C.sub.4 alkyl esters of short-chain acids and polytetrahydrofuran ethers. When these are indeed present, such solvents preferably constitute from 1% to 80% by weight of the total weight of the composition.

The medium may be thickened using thickening agents typically employed in cosmetics or in pharmaceuticals.

Among these thickening agents, particularly exemplary are cellulose and derivatives thereof such as cellulose ethers, heterobiopolysaccharides such as xanthan gum, scleroglucans, and polyacrylic acids which either may or may not be crosslinked.

The thickening agents are preferably present in proportions ranging from 0.1% to 5% by weight approximately relative to the total weight of the composition.

Depending on the intended application of the subject compositions, one skilled in this art can easily select the particular compounds and adjuvants that are necessary and characteristically employed to formulate these compositions.

Among these adjuvants or additives, especially representative are preservatives, stabilizing agents, pH regulators, osmotic pressure modifiers, emulsifying agents, sunscreen agents, antioxidants, fragrances, colorants, anionic, cationic, nonionic, amphoteric or zwitterionic surface-active agents or mixtures thereof, polymers, and the like.

In addition to the particular antifungal/antibacterial species according to the invention, the subject compositions may also contain compounds already known for reducing or decelerating hair loss.

This invention also features a cosmetic treatment for the hair and/or the scalp, comprising applying thereto a composition as described above, for the purpose of reducing hair loss.

The preferred regime or regimen of application comprises applying 1 to 20 g of the composition to all or to certain parts of the scalp, at a frequency of one to two applications per day, for 1 to 7 days per week, for a period of time of from 1 to 6 months or even longer.

In order to further illustrate the present invention and the advantages thereof, the following specific examples are given, it being understood that same are intended only as illustrative and in nowise limitative.


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