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Hair Loss Patent

Topical sod for treating hair loss

Hair loss abstract


SOD for treating hair loss is disclosed. The SOD has utility in a topical pharmaceutical formulation for the cosmetic treatment of hair loss and the cosmetic stimulation of hair growth. The SOD comprises copper salicylate, copper aspirinate, indomethacin-copper, or a complex of an amino acid or peptide and a transition metal.

Hair loss claims


I claim:

1. A method for stimulating hair growth comprising the step of:

applying in a topical pharmaceutical carrier to skin a transition metal compound having SOD activity, said compound selected from copper salicylate, copper aspirinate, indomethacin-copper and a complex of an amino acid or peptide and a transition metal, wherein the peptide consists of amino acids selected from glycine, histidine, lysine, arginine, cysteine or methionine.

2. The method of claim 1, wherein the amino acid of the amino acid-metal complex is selected from glycine, histidine, lysine, arginine, cysteine and methionine, and the metal is selected from copper, iron, zinc and manganese.

3. The method of claim 1, wherein the peptide is selected from histidyl lysine, glycyl histidine, glycyl hystidyl lysine and lysyl histidyl lysine.

4. The method of claim 1, wherein the transition metal compound is copper salicylate.

5. The method of claim 1, wherein the transition metal compound is copper aspirinate.

6. The method of claim 1, wherein the transition metal compound is indomethacin-copper.

7. a composition suitable for treating hair loss, comprising:

a transition metal compound having SOD activity selected from copper salicylate, copper aspirinate, indomethacin-copper, and a complex of a basic amino acid and a transition metal; and

a topical pharmaceutical carrier selected from oil and water emulsions, urea, propanol, butanol and glycols.

8. The composition of claim 7, wherein the amino acid is selected from glycine, histidine, lysine, arginine, cysteine and methionine, and the metal is selected from copper, iron, zinc and manganese.

9. The composition of claim 7, wherein the transition metal compound is copper salicylate.

10. The composition of claim 7, wherein the transition metal compound is copper aspirinate.

11. The composition of claim 7, wherein the transition metal compound is indomethacin-copper.

12. A composition useful for treating hair loss, comprising:

a transition metal compound of the formula R-M having superoxide dismutase activity wherein R is salicyl, acetylsalicyl or indomethacin, and M is copper, iron, zinc, or manganese; and

a topical pharmaceutical carrier selected from creams, lotions, shampoos and cream rinses.

13. The composition of claim 12, wherein R is salicyl.

14. The composition of claim 12, wherein R is acetylsalicyl.

15. The composition of claim 12, wherein R is indomethacin.

16. The composition of claim 12, wherein M is copper.

17. The composition of claim 12, wherein M is iron.

18. The composition of claim 12, wherein M is zinc.

19. The composition of claim 12, wherein M is manganese.

Hair loss description

FIELD OF THE INVENTION

This invention relates to topical superoxide dismutase (SOD), and the treatment of hair loss herewith.

BACKGROUND OF THE INVENTION

Recently, several anti-alopecia agents such as minoxidil and cyoctol have gained attention. However, most of these anti-alopecia agents are only minimally effective in some cases and/or can cause adverse dermatological or systemic reactions. Minoxidil, for example, is a therapeutic antihypertensive. Thus, the search continues for new, safer and more effective anti-alopecia agents which can be used without the risk of undesirable antihypertensive effects.

SUMMARY OF THE INVENTION

Applicant has discovered that SOD can be used as a topical anti-alopecia agent which can desirably be essentially free of antihypertensives, for example, to stimulate cosmetic hair growth.

In one embodiment, the present invention provides a method for stimulating hair growth. The method comprises the step of applying to skin in a topical pharmaceutical carrier a transition metal compound having SOD activity. The SOD active compound is selected from one or more of copper salicylate, copper aspirinate, indomethacin-copper and a complex of an amino acid or peptide and a transition metal. The amino acid is selected from one or more of glycine, histidine, lysine, arginine, cysteine and methionine, and the metal is selected from one or more of copper, iron, zinc and manganese. The peptide consists of glycine, histidine, lysine, arginine, cysteine or methionine. The peptide is selected from one or more of histidyl lysine, glycyl histidine, glycyl hystidyl lysine and lysyl histidyl lysine.

In another embodiment, the present invention provides a composition suitable for treating hair loss. The composition comprises a transition metal compound having SOD activity formulated in a suitable topical pharmaceutical carrier. The SOD active compound is selected from copper salicylate, copper aspirinate, indomethacin-copper and a complex of an amino acid and a transition metal. The amino acid is selected from glycine, histidine, lysine, arginine, cysteine and methionine, and the metal is selected from copper, iron, zinc and manganese.

In a further embodiment, the present invention provides a composition useful for treating hair loss comprising a transition metal compound of the formula R-M having superoxide dismutase activity. R is a salicyl, acetylsalicyl or indomethacin group and M is copper, iron, zinc or manganese. The composition includes a topical pharmaceutical carrier.

DETAILED DESCRIPTION OF THE INVENTION

In the present invention, superoxide dismutase (SOD) is compounded in a topical formulation. The pharmaceutical carrier, in which the SOD is generally substantially homogeneously dispersed can be an aqueous dispersion or suspension, or a water-in-oil or oil-in-water emulsion. Pharmaceutical carriers which can be mentioned include water, urea, alcohols and glycols such as methanol, ethanol, propanol, butanol, ethylene glycol, propylene glycol, and the like.

Suitable water-in-oil emulsions are commercially available under the designations Aquaphor, cold cream, Eucerin, hydrous lanolin, Hydrosorb hydrophilic petrolatum, Nivea, Polysorb, Qualatum and Velvachol. Suitable oil-in-water emulsions are available commercially under the designations acid mantle cream, Almay emulsion cream, Cetaphil, Dermabase, Dermavan, hydrophilic ointment, Keri cream, Lubriderm cream, Multibase cream, Neobase cream, Unibase cream, Vanibase cream and Wibi. The carrier may further contain various other emollients, emulsifiers, water, perfumes, colorants, preservatives, and the like. The topical formulation is in the form of a cream, lotion, shampoo, cream rinse, or the like.

The SOD can be enzymatic or an enzyme mimic, such as, for example, metal complexes of amino acids, peptides and other organic acids. Complexes of zinc and the transition metals, typically copper, iron and manganese, are known to have SOD activity. Preferred amino acids and peptides include the amino acids glycine, histidine, lysine, arginine, cysteine, methionine, and the like, and peptides comprised predominantly thereof. Representative examples include copper salicylate, copper aspirinate and indomethacin-copper.

Effective amounts of the SOD generally range from about 0.01 to about 20% by weight of the topical composition, more preferably from about 0.1 to about 10% by weight, most preferably from about 0.5 to about 3% by weight, but more or less can be present in the composition depending on the particular SOD formulation and the treatment conditions. In general, topical applications to the scalp of SOD having about 300 units of activity per application, or more, are sufficient.

The topical SOD can be used alone or in combination with other hair growth stimulants or additaments ,which are available to enhance hair growth stimulation, such as, for example, the hydroxyl radical scavengers, antiandrogens and others described in International Publication No. WO 87/00427 (International Application No. PCT/US86/01393) published on Jan. 29, 1987; and European Patent Application No. 89300785.6, Publication No. 0327263/A1, published Aug. 9, 1989; both of which are hereby incorporated in their entirety herein as though fully set forth verbatim, including reference therein to the publication of Ross & Ross, "Selected Specific Rates of Reactions of Transients From Water In Aqueous Solution. III. Hydroxyl Radical and Pure Hydroxyl Radicals and Their Radical Ions," National Standard Reference Data Series, National Bureau of Standards, 59 (1977), which is also incorporated herein by reference.


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