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Weight Loss Patent

Herbal appetite suppressant and weight loss composition

Weight loss abstract


The present invention is directed to herbal compositions which reduce weight, maintain weight loss over an extended period of time, and act as an appetite suppressant. The composition consists of St. John's Wort with or without caffeine or other appetite suppressants known in the art, and also a composition comprising St. John's Wart (Hypericum perforatum) and Mahuang (Ephedra sinica or ephedrine). Another composition disclosed comprises a combination of the above herbs with caffeine.

Weight loss claims


What is claimed is:

1. A composition comprising a dosage taken twice a day of St. John's Wort and Mahuang extract in an amount effective for reducing weight and maintaining the weight loss for an extended period of time wherein St. John's Wort is present in an amount ranging from 10 mg per day to 2500 mg per day.

2. The composition of claim 1 wherein the preferred daily dosage of St. John's Wort is 400 mg per day to reduce weight and control appetite.

3. The composition of claim 1 wherein the preferred daily dosage of St. John's Wort is 800 mg per day to reduce weight and control appetite.

4. The composition of claim 1 further comprising an effective amount of caffeine.

5. The composition of claim 1 in unit dosage form.

6. The composition of claim 1, further comprising an agent selected from the group consisting of electrolytes, buffers, colorants, aromatic agents, flavoring agents, emulsifying agents, compounding agents, formulation agents, permeation enhancers, other weight reduction agents, and bulking agents.

7. The composition of claim 1 in sustained release form.

8. The composition of claim 1 wherein the dosage of Mahuang is from 5 to 1500 mg per day.

9. The composition of claim 8 wherein Mahuang is present at a preferred concentration of 250 mg per dose.

10. The composition of claim 8 wherein Mahuang is present at a preferred concentration of 125 mg per dose.

11. The composition of claim 1 in sustained release form.

12. A method or reducing and controlling weight comprising the steps of:

administering twice a day to a subject a composition of St. John's Wort and Mahuang extract in an amount effective for reducing weight and maintaining the weight loss for an extended period of time wherein St. John's Wort is present in an amount ranging from 10 mg per day to 2500 mg per day and after a predetermined weight is attained, a weight maintaining effective amount of the composition.

13. The composition of claim 1 wherein the preferred dosage comprises St. John's Wort in a 400 mg dose which is taken twice per day, and Mahuang in a 250 mg dose which is also taken twice per day.

14. The composition in accordance with claim 13 wherein each 400 mg dose of St. John's Wort is combined with 250 mg dose of Mahuang two such combined pills being taken per day.

15. The composition in accordance with claim 1 wherein the dosages are taken before breakfast and before dinner.

16. The composition in accordance with claim 15 wherein the dosages are taken with a glass of water.

17. The composition in accordance with claim 1 wherein the St. John's Wort is an extract of St. John's Wort which contains the active ingredient 0.3% hypericin.

Weight loss description

FIELD OF THE INVENTION

The invention relates to compositions for reducing weight in humans and/or animals and more particularly to herbal compositions for achieving the desired result.

BACKGROUND OF THE INVENTION

This invention relates to herbal compositions for reducing weight, maintaining weight loss over an extended period of time and suppressing appetite in a human or a domestic animal.

Examples of known appetite reducing agents are ephedrine which is an extract of the herb Mahuang (Ephreda sinica), phenylpropanolamine (PPA), amphetamines and fenfluramine alone or in combination with caffeine. Caffeine functions probably to reduce fatigue as caffeine has stimulating properties. Phenylpropanolamine (PPA) is a popular over-the-counter drug for appetite suppression and its side effects are well documented.

Several herbal compositions have been developed for reducing weight in humans or domestic animals. U.S. Pat. No. 5,422,352 discloses a composition of ephedrine and caffeine in a ratio of about 1:12. U.S. Pat. No. 5,019,594 discloses a method for decreasing appetite by administering a composition containing ephedrine or other indirect acting sympathomimetic drugs and tyrosine. U.S. Pat. No. 5,273,754 discloses an appetite suppressant composition comprising a heating and a cooling carminative substance, which composition may also include an amino acid and an anxiolytic substance. One of the anxiolytic substances disclosed is St. John's Wort. U.S. Pat. No. 5,543,405 discloses a weight reduction composition comprising a sympathomimetic agent and a mineral cation salt or chelate. Preferred is a composition comprising ephedrine and chromium picolinate. U.S. Pat. No. 5,055,460 discloses a composition for reducing weight comprising ephedrine, acetylsalicylic acid and caffeine.

However, none of the methods for weight reduction or appetite suppression disclose a composition comprising St. John's Wort (hypercin) and Mahuang (Ephedra sinica or ephedrine) which are disclosed in the present invention. The synergistic effect of St. John's Wort and Mahuang have been shown to be unexpectedly superior than the effect of the individual components.

SUMMARY OF THE INVENTION

The present invention discloses herbal compositions effective in reducing weight, maintaining weight loss and suppressing appetite comprising St. John's Wort (Hypericum perforatum), and a composition comprising St. John's Wort and Mahuang (Ephedra sinica or ephedrine). When taken in combination, St. John's Wort and Mahuang act synergistically to increase serotonin levels in the brain to effect appetite suppression and caloric expenditure increase in the body. These weight reduction and appetite suppressant compositions are presented in a variety of formulations, with or without other weight reduction active ingredients such as phenalpropanolamine and caffeine.

Studies conducted by applicant have proven the effectiveness of the composition.

BRIEF DESCRIPTION OF THE INVENTION

It is a well established fact that overweight and obesity is an unhealthy condition. It is therefore logical that substances aiding or resulting in weight reduction would be beneficial to a society where millions suffer from obesity, as long as the substance is safe and effective when taken as directed. This condition may be related to a genetic trait and/or to environmental factors. See, generally, Ravussin, Lillioja, Knowler, Reduced Rate Of Energy Expenditure As A Risk factor For Body Weight Gain, New Jr. Eng. of Med., 318, p. 467, 1988.

Over-weight and obesity are chronic conditions which are highly prevalent in industrialized society. These conditions are associated not only with social stigma but are also associated with decreased longevity and numerous medical problems such as diabetes, reproductive disorders, dermatological disorders, varicose veins, arthritis, heart disease, cancer, etc.

Over-weight and obesity is a condition characterized by the excessive accumulation of fat in the body as a consequence of an energy intake which is greater than energy expenditure. Over-weight is present if the body weight exceeds a "desirable weight", whereas obesity represents a condition where the weight is 20% or more above the desirable weight. Desirable weight for humans is defined in the Metropolitan Height And Weight tables as the midpoint of the range of medium frame individuals. See, JAMA,260, 2547-48, 1988.

Existing therapies for over-weight and obesity basically include a treatment to establish a negative energy balance. This may be accomplished by reduction of energy intake, for example, a low calorie diet; or an increase in energy expenditure, for example, by increased physical exercise; or by ingestion of a sympathomimetic drug which stimulates thermogenesis, i.e., increases the metabolic rate of the body in humans and animals. Known thermogenic drugs are ephedrine, phenylpropanolamine and caffeine. See, for example, Astrup, A. V., Treatment Of Obesity With Thermogenic Agents, Nutrition, 5, p. 70, 1989; Bray, Nutrition Reviews, 49, p. 33, 1991. While energy expenditures may increase 10-fold during exercise, the thermogenic effect of pharmacological agents is much more modest. Sympathomimetic compounds and beta adregenic agonists can increase resting energy expenditure by 10% to 15% and slightly potentiate the effect of foods. Energy expenditure may be increased 5% to 10% on a 24-hour basis. See, generally, Astrup, Breum, Tourbo, Pharmacological And Clinical Studies Of Ephedrine And Other Thermogenic Agonists, Obesity Research, 3, p. 537, 1995.

Drugs which are used for reducing weight or obesity suppress appetite by acting on the noradrenergic neurotransmitter such as mazindol and derivatives of phenethylamine, for example, phenylpropanolamine, phentermine, amphetamine, methamphetamine. Also well known in the art are the use of drugs which act on the serotonin neurotransmitter such as fenfluramine, tryptophan, fluoxetine and sertraline. However, all these drugs have side effects.

There is, therefore, a need for a drug which will reduce the weight of overweight or obese persons without side-effects and which will also help obese and overweight subjects maintain the reduced weight level.

OBJECTS OF THE INVENTION

It is therefore an object of the present invention to provide a regimen that is useful in returning the body weight of overweight or obese subjects to a lower and preferably normal body weight.

It is another object of the present invention to provide a therapy for overweight or obesity that results in maintenance of the lowered body weight over an extended period of time.

BRIEF DESCRIPTION OF THE FIGURES

FIGS. 1-4 are graphs useful in presenting data compiled during testing of the present invention.

DETAILED DESCRIPTION OF THE INVENTION AND PREFERRED EMBODIMENTS THEREOF

The present invention is directed to a composition comprising St. John's Wort (hypercin) and Mahuang (Ephreda sinica, or its extract ephedrine).

St. John's Wort is a herb of the hypericaceae family which contains the therapeutically active ingredient hypercin. St. John's Wort has antidepressant properties for which it is widely used in Europe. Numerous publications and meta-analysis strongly suggests the antidepressant efficacy through seratonergic mechanisms. However, it was unexpectedly found that St. John's Wort also functions to reduce weight and also acts as an appetite suppressant, most likely by controlling serotonin levels. See BMJ 1996; 313:253-8 St. John's Wort for Depression--An Overview and Meta-analysis Of Randomized clinical Trials; K. Linde, et al.

The dosage form of St. John's medication contains its extract at a concentration of 0.3% hypercin. For efficacy in providing weight reduction, St. John's Wort should be present in an amount ranging from 10 mg to 2500 mg per dose per day, preferably from 100 mg to 800 mg per dose per day, and most preferably at a concentration of two doses of 400 mg each per day. Other weight reduction compositions such as caffeine may be taken with St. John's Wort.

Another composition which is effective in reducing weight and suppressing appetite is a composition comprising St. John's Wort (hypercin) and Mahuang (Ephedra sinica or ephedrine). Mahuang is also a naturally occurring herb which aids in weight reduction through its active ingredient the sympathomimetic compound Ephedra sinica or its extract ephedrine. When used in combination with St. John's Wort, Mahuang should be present in an amount ranging from 5 mg to 1500 mg per dose per day, and most preferably at a concentration of two doses of 250 mg each per day.

Both St. John's Wort and Mahuang are safe and effective when used as directed and side effects are minor or none. High doses of Mahuang are associated with sympathomimetic simulation and attendant side effects. Accordingly, low doses are recommended in the medication and subjects who have high blood pressure or cardiac arrhythmias are not good candidates for this drug regimen.

Mahuang be taken separately in the morning and St. John's Wort in the afternoon before dinner, or both may be taken in the morning and before dinner.

Good results were observed in a clinical study conducted at St. Lukes/Roosevelt Hospital, New York according to the present invention by using a pharmaceutical tablet composition comprising St. John's Wort and Mahuang in overweight or obese subjects. The results of the clinical studies detailed below clearly demonstrate that the action exerted by the combination of St. John's Wort and Mahuang is due to an unexpected synergistic effect of the two drugs.

The herbal components (St. John's Wort and Mahuang) may be used for weight reduction and appetite suppressant without being further processed, or they may be used as extracts thereof. For example, St. John's Wort herb may be dried, powdered and used in the powdered form as the active ingredient in a oral dosage form such as a pill or a capsule. Alternatively, hypercin, the active ingredient of St. John's Wort may be extracted from the herb by soaking the crushed herb in an alcohol/water solution and the extracted active ingredient dried by spray drying or evaporation.

The composition according to the present invention may be formulated for administration by any conventional route such as oral, rectal, nasal, topical (dermal) or parenteral. Thus the composition may be in the form of tablets, capsules, suspensions, emulsions, solutions, suppositories, sprays or injectibles. Formulations for oral use include tablets which contain the active ingredient in admixture with pharmaceutically acceptable inert excipients. These excipients may be, for example, inert diluents such as calcium carbonate, sodium chloride, lactose, calcium phosphate, sodium phosphate, etc.; granulating and disintegrating agents, for example, potato starch, alginic acid, etc.; binding agents, for example, starch, gelatin or acacia, etc.; and lubricating agents for example, magnesium stearate, stearic acid or talc. Other pharmaceutically acceptable excipients can be colorants, flavoring agents, plasticizers, humectants, etc. The tablets may be uncoated or they may be coated by known techniques.

Alternatively, the active ingredients of the weight reduction formulation may be delivered over an extended time period by delaying disintegration and absorption in the gastrointestinal tract to provide a sustained release effect. For example, a time delay material such as glyceral monostearate or glycerol distearate may be employed. The active ingredient may be placed in an extended release dosage form by techniques which are well known in the art. See, for example, Baker, Richard, Controlled Release Of Biologically Active Agents, John Wiley And Sons, 1986.

The inactive excipients in a tablet may include calcium carbonate, dicalcium phosphate, microcrytalline cellulose, croscarmellose sodium, stearic acid, silica, magnesium stearate and pharmaceutical glaze. Alternatively, the active ingredient or extract thereof may be delivered in a soft or hard gel capsule by mixing the active ingredient with water or an oil medium such as peanut oil, liquid paraffin, or olive oil and enclosing it within the capsule or gel capsule.

The dosage may also be administered as an oral liquid dosage form by suspending the active ingredients or extracts thereof in an aqueous solution in admixture with a dispersing or wetting agent, suspending agent and one or more preservatives. Suitable dispersing or wetting agents are, for example, naturally occurring phosphatides, for example, lecithin, or condensation products of ethylene oxide, fatty acids, long chain aliphatic acids, or a partial ester derived from fatty acids and a hexitol or hexitol anhydrides, for example, polyoxyethylene stearate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitan monooleate, etc. Suitable suspending agents are, for example, sodium carboxymethylcellulose, methylcellulose, sodium alginate, etc.

The pharmaceutical formulation may also be delivered parenterally in dosage forms containing conventional pharmaceutically acceptable carriers and adjuvants. The formulation and preparation of such compositions is well known to those skilled in the art. For example, specific formulations can be found in the text Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton, Pa., 1995. The active ingredients may be dissolved in vehicles such as water, isotonic sodium hydroxide solutions, etc. The aqueous formulations may also contain a preservative such as methyl, ethyl or n-propyl p-hydroxybenzoate.

For rectal applications, suitable dosage forms for a composition according to the present invention include suppositories (emulsion or suspension type), and rectal gelatin capsules (solution or suspensions). In a typical suppository formulation, the active ingredients of the two herbs are combined with an appropriate pharmaceutically acceptable suppository base such as cocoa butter, esterified acids, glycerinated gelatin, and various water soluble or dispersible bases like polyethylene glycols and polyoxyethylene glycols and polyoxyethylene sorbitan fatty acid esters.

To prepare the weight loss and appetite suppressant of the present invention in a tablet form, the extract of the two herbs were combined with excipients in an appropriate ratio and thereafter tableted by methods which are well known in the art. See, for example, Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton, Pa., 1995.

EXAMPLE 1

Overweight and obese patients were placed on a low calorie diet and a daily dosage of St. John's Wort effective to control appetite and reduce weight and maintain the weight loss is 10 mg to 2100 mg per day, with and without caffeine. It was found that over a two month period, over 90% of the subjects lost an average of 4 pounds per month, were able to maintain the weight loss, and reported a decreased craving for food and a decreased appetite.

EXAMPLE 2

A dose response open-label study of the thermogenic effect of St. John Wort in combination with Mahuang was conducted under the direction of Dr. Joseph D. Bartolomeo, Ph.D. The concentration range over which Mahuang is effective to control appetite, reduce weight and maintain the weight loss is from 10 mg to 2500 mg per day.

The aim of the study was to assess the effectiveness, tolerability and safety of oral administration of St. John's Wort at a dosage of 400 mg twice daily and a Mahuang dosage of 250 mg twice daily over a 6 week period for the treatment of overweight and appetite suppression. Changes in weight and body composition measurements were primary effectiveness variables. The aim of the study was to determine if fat is preferentially lost when the two herbs are combined with the diet. Appetite suppression was a secondary effectiveness variable.

The study was conducted in subjects with a body mass index of 27 to 32 kg/square meter. Fifteen overweight but otherwise healthy subjects were selected at random for the study. The subjects were supplied with two weeks supply of 28 caplets and one of three calorie diet plans. The subjects were directed to swallow a caplet comprising 200 mg St. John's Wort caplet and one 125 mg caplet of Mahuang 30 to 60 minutes before breakfast and to repeat the same dosage before dinner with a glass of water.

Specifically excluded from this study were subjects who required or were currently taking any significant medication other than analgesics on an occasional basis such as drugs containing sympathomimetics amines, MAO inhibitors and other drugs indicated for weight reduction.

The subjects were instructed to visit the clinic every week to weigh-in and pick up the necessary St. John's Wort and Mahuang tablets. On each visit the subjects were also monitored for blood pressure, temperature, body fat by bioimpendence analysis and anthropometry, and circumference measurements of the chest, waist and hips.

At the end of the six weeks study, the 12 subjects lost an average of 8 pounds. The subjects also reported on the effects of the herbal therapy as it related to appetite control, feeling of fullness and snack cravings. 87% of the subjects reported a suppression of appetite; 81% reported satisfaction with less food during a meal, and 81% reported that they were less inclined to snack between meals.

EXAMPLE 3

An open label trial study was conducted in which data was collected, analyzed, summarized, and presented as a poster at the North American Association for Study of Obesity in November 1997. The following data includes the study abstract, weight loss results, and reported side effects (the results indicate that the subjects placed on the product on average lose weight over the 8 weeks of follow-up and reported side effects are, on the whole, minor): OPEN-LABEL WEIGHT LOSS TRIAL OF COMBINATION HERBAL MA HUANG AND ST. JOHN'S WORT. Steven B. Heymsfield. Obesity Research Center, St. Luke's/Roosevelt Hospital, Columbia University, NY, N.Y. 10025.

Objective. Ma Huang and St. John's Wart with active agents ephedra and hypercin through sympathomimetic and serotonergic actions may produce appetite suppression and weight loss. This pytothesis was tested in this first open-label trial and a randomized double blind study is now in progress (study results of double blind study are set forth under Example 4 below).

Design. Open label 8 week ongoing safety study in obese adults.

Materials and Methods. Subjects were healthy adults in whom the herbs (40 mg/d ephedra and 800 mg/d hypericin) were not contraindicated. Weight loss, blood pressure, and symptoms were monitored over the 8 week treatment period.

Results. 1401 subjects and baseline evaluations; 748 have now completed 4 weeks; and 68 completed 8 weeks of treatment. Weight in subjects at 4 weeks (mean .DELTA.=1.72 pds/wk) and 8-wks (mean .DELTA.=1.40 pds/wk; plotted in FIG. 1) shows classic exponential weight-decline. Symptoms for pooled 1401 subjects were minimal (see Table). Blood pressure was unchanged from baseline for all subjects at last evaluation.

______________________________________ Symptom % ______________________________________ Allergic 0.2 Incr. BP 0.3 Palpitations 0.2 Jittery 1.4 Disturb 0.5 Sleep Headache 0.3 Fatigue 0.2 Dry mouth 1.5 ______________________________________

Conclusion: This ongoing open label trial of an herbal combination produced weight loss with minimal symptoms. These findings led to initiation of the double blind phase (Example 4).

METHODS

Subjects

Subjects were healthy adults in whom the herbs were not contraindicated.

Protocol

Open label 8 week safety study in obese adults. Weight loss, blood pressure, and symptoms were monitored over the 8 week treatment period.

Results

1401 subjects had baseline evaluations; 748 completed 4 weeks; and 68 completed 8 weeks of treatment.

Subject age distribution is presented in a Figure.

Weight in subjects at 4 wks (mean change=1.72 pds/wk) and 8-wks (mean change=1.40 pds/wk; plotted in FIG. 2) shows classic exponential weight-decline. Symptoms for pooled 1401 subjects were minimal (Table).

Blood pressure was unchanged from baseline for all subjects at last evaluation (Table).

Reported side effects for the 1401 subjects at the time of analysis are summarized in the Table below. Side effects were minimal and similar in profile to previous ephedra reports.

______________________________________ BLOOD PRESSURE Baseline Final SYSTOLIC DIASTOLIC SYSTOLIC DIASTOLIC ______________________________________ MEAN 117.6 75.2 116.8 74.8 SD 13.7 9.3 32.9 20.1 ______________________________________ REPORTED SIDE EFFECTS SIDE EFFECTS NUMBER ______________________________________ Sleeping Disturbance 8 Gastrointestinal 7 Dry Mouth 17 Lethargy 3 Allergic 3 Nervousness 18 Palpitations 6 Blood Pressure Increase 5 Shortness of Breath 2 Headaches 4 Chest Pains 2 Sun Senstive 1 ______________________________________

EXAMPLE 4

A double blind investigation of two numbered products, one active medication and the other placebo was conducted. The following is a review of results.

The active product tested was a combination of St. John's Wort and Ma Huang. St. John's Wort is a naturally occurring herb that has antidepressant properties and is widely used in Europe. Numerous publications and a meta-analysis strongly suggests efficacy, most likely through seratonergic mechanisms.

This study evaluated an extract of St. John's Wort which contains the active ingredient 0.3% hypercin (Hypericum perforatum herb). Two pills provide a 400 mg dose and are taken twice per day. Total dose is 800 mg.

Ma Huang is also an herbal supplement which may aid in weight reduction through its active ingredient the sympathomimetic compound ephedra sinica herb. Two pills provide 250 mg and are taken twice per day. Total dose is 500 mg.

The combined medication (Mahuang and St. John's Wort) is taken is taken in the morning and in the afternoon before dinner.

The aim of the second study was to assess the tolerability, safety, and weight loss properties of the above plan (2 caplets of Ma Huang plus St. John's Wort) in the morning before breakfast and two caplets in the evening before dinner in the double-blind treatment of overweight subjects over a 12 week period.

A total of 111 subjects were evaluated at base-line and 81 were randomized at week 0 within 3 weeks to either product identified as 325 or identified as 916. Base-line evaluations included medical, nutritional, and psychological studies. Following randomization at week 0, subjects returned every two weeks for medication count, symptom evaluation, blood pressure-vital sign check, and psychological/hunger studies. On the final week 12 visit subjects had repeat baseline studies.

A total of 32 subjects were randomized to product 325 and 49 to 916. Of those randomized, 26 in the 325 group and 33 in the 916 group completed 12 weeks of study. Thus 59 subjects or 72.8% completed the study, 81% in 325 and 67% in 916 groups. The chart set forth hereinbelow provides a summary of subjects who dropped from study.

Three relevant items are summarized below: Weight; Hunger rating; and adverse events.

Weight

As the number, weight, and sex distribution of completed subjects varied between groups, assessing comparative weight change requires balancing initial weight between groups. The groups were balanced by matching weights and gender at the screening evaluation. A few missed-weights were also interpolated so that mean values could be computed on a per visit basis. The tables give the mean and standard deviation weight at each visit and FIG. 3 presents a plot of this information. Weight loss on product 916 exceeded that of product 325 by the final visit. The mean weight losses on 916 and 325 were 0.88 pounds/week and 0.66 pounds/week, respectively. In unmatched subjects the absolute weight loss was 11.8.+-.9.0 and 7.7.+-.7.8 pounds in the 916 and 325 groups (p=0.05), respectively.

______________________________________ PRODUCT WEEK 0 2.0 4.0 6.0 8.0 10.0 12.0 ______________________________________ 325 mean 179.5 176.5 175.4 173.8 173.0 172.6 171.6 SD 26.3 26.0 26.9 26.6 28.2 27.7 29.0 Change 3.0 4.1 5.7 6.5 6.9 7.9 916 mean 179.8 175.3 173.7 172.4 170.5 169.7 169.2 SD 24.6 24.9 24.3 24.2 22.8 22.8 23.9 Change 4.5 6.1 7.4 9.3 10.1 10.6 ______________________________________

The pulse of the subjects presented above was as follows:

______________________________________ WEEK 0 2.0 4.0 6.0 8.0 10.0 12.0 ______________________________________ 325 mean 71 74 71 70 71 72 71 SD 10 10 8 7 7 8 9 916 mean 71 68 71 69 68 69 70 SD 11 7 8 6 7 8 8 ______________________________________

No pulse trend is evident.

The systolic blood pressure of the subjects presented above was as follows:

______________________________________ WEEK 0 2.0 4.0 6.0 8.0 10.0 12.0 ______________________________________ 325 mean 120 115 117 116 118 116 118 SD 11 10 10 11 13 9 16 916 mean 113 121 119 116 115 117 117 SD 11 16 11 8 11 12 14 ______________________________________

No blood pressure trends are evident from the chart.

Hunger ratings, by visual analog scale, were as follows for the above subjects:

______________________________________ WEEK 0 2.0 4.0 6.0 8.0 10.0 12.0 ______________________________________ 325 mean 4.35 3.75 3.56 4.08 3.88 4.88 4.49 SD 2.24 2.49 2.74 2.12 2.62 2.73 2.49 Change 0.60 0.79 0.27 0.47 -0.53 -0.14 916 mean 5.02 3.41 3.14 3.33 3.50 3.74 4.38 SD 1.92 2.00 2.50 2.23 1.68 1.87 1.42 Change 1.61 1.88 1.69 1.52 1.28 0.64 ______________________________________

As can be seen from FIG. 4, product 916 caused a greater hunger reduction over time than 325. Negative values represent greater hunger reduction. Hunger tended to return towards baseline over time for both products with 325 at baseline levels by study end.

Side effects on the whole were minor. They were as follows:

______________________________________ SYMPTOM 325 n(%) 916 n(%) ______________________________________ Allergic 0 0 Incr. BP 0 0 Palpitations 0 2 Jittery 0 1 Disturb Sleep 0 1 Headache 0 0 Fatigue 0 0 Dry Mouth 0 0 Other (misc minor) 11 0 ______________________________________

Two 916 patients dropped from study because of dizziness or jittery feelings. The reasons for dropping out are shown on the following chart:

______________________________________ REASON FOR PERSON DROPPED DROPPING CODE SEX ______________________________________ DA Does not return 325 F calls - 2 visits AJ did not return 325 F calls - 3 visits BB felt meds. did 325 F not work - 2 visits KB failed to come - 325 F 2 visits PR failed to call - 325 F 2 visits BP heard about bad 325 F side effects - 1 visit EC not interested - 916 F 1 visit DD long vacations - 916 F 3 visits WC no time for study - 916 F 2 visits MJP nervous about 916 F meds. - 3 visits BB moved to DC - 4 916 F visits AM unreliable - 1 916 F visit MH unreliable - 4 916 F visits SG canceled appts. - 916 F 4 visits CR failed to call - 916 F 1 visit CG car accident - 1 916 F visit TF failed to call 916 M DY never returned or 916 M phoned - 1 visit ______________________________________

These observations, interpreted within the executed study context, suggest that: both 325 and 916 are safe over 12 weeks of follow-up; and product 916 produces both greater weight loss and hunger suppression than product 325.

______________________________________ Person Reason for Dropped Dropping Code Sex ______________________________________ DA Does not re- 325 F turn calls - 2 visits AJ Did not 325 F return calls - 3 visits BB felt meds. 325 F did not work - 2 visits KB failed to 325 F call - 2 visits PR failed to 325 F call - 2 visits BP heard about 325 F bad side effects - 1 visit EC not 916 F interested - 1 visit DD long 916 F vacations - 3 visits WC no time for 916 F study - 2 visits MJB nervous about 916 F meds. 3 - visits BB moved to DC - 916 F 4 visits AM unreliable - 916 F 1 visit MH unreliable - 916 F 4 visits SG cancelled 916 F appts. - 4 visits CR failed to 916 F call - 1 visit CG car accident - 916 F 1 visit TF failed to 916 M call DY never returned 916 M or phoned - 1 visit ______________________________________

It will be apparent to one of ordinary skill in the art that many changes and modifications can be made to the present disclosure without departing from the spirit and scope of the invention as set forth herein.

A latitude of modification, change and substitution is intended in the foregoing disclosure, and in some instances, some features of the invention will be employed without a corresponding use of other features. Accordingly, it is appropriate that the appended claims be construed broadly and in a manner consistent with the spirit and scope of the invention herein described.


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